UNUSUAL PRESENTATION OF WILSON’S DISEASE. MRI BASED CASE REPORT AND REVIEW OF LITERATURE

Mahum Zaidi; Rizwan Ajmal; Bushra Rehan; Muhammad Wasif

UNUSUAL PRESENTATION OF WILSON’S DISEASE. MRI BASED CASE REPORT AND REVIEW OF LITERATURE

Mahum Zaidi, Rizwan Ajmal, Bushra Rehan, Muhammad Wasif

Abstract

Abstract:

This is a case of a 28 year old male,known case of Wilson’s disease with CLD. He received D- Penicillamine for last 7 years but stopped treatment 6months back. MRI done 7 years back showed features of high signals within caudate and lentiform nuclei. Fresh MRI brain was ordered which to our surprise showed atrophy of caudate and lentiform with regression in high signals as compared to previous scan along with this, subtle high signals on diffusion weighted images were seen in Parieto-occipital cortex bilaterally, which are not the usual sites of involvement in Wilson’s disease.

Full Text:

PDF

References

References:

Starosta-Rubinstein S, Young AB, Kluin K, Hill G, Aisen AM, Gabrielsen T, Brewer GJ. Clinical assessment of 31 patients with Wilson's disease. Arch Neurol. 1987;44:365-70. (https://jamanetwork.com/journals/jamaneurology/article-abstract/586287)

Walshe JM, Yealland M. Wilson's disease: the problem of delayed diagnosis. Journal of Neurology, Neurosurgery & Psychiatry. 1992 Aug 1;55(8):692-6. (https://jnnp.bmj.com/content/55/8/692.short)

Kim TJ, Kim IO, Kim WS, Cheon JE, Moon SG, Kwon JW, Seo JK, Yeon KM. MR imaging of the brain in Wilson disease of childhood: findings before and after treatment with clinical correlation. American journal of neuroradiology. 2006 Jun 1;27(6):1373-8.

(http://www.ajnr.org/content/27/6/1373.short)

Sener RN. Diffusion MR imaging changes associated with Wilson disease. American journal of neuroradiology. 2003 May 1;24(5):965-7.

(http://www.ajnr.org/content/24/5/965.short)

Kozić DB, Petrović I, Svetel M, Pekmezović T, Ragaji A, Kostić VS. Reversible lesions in the brain parenchyma in Wilson's disease confirmed by magnetic resonance imaging: earlier administration of chelating therapy can reduce the damage to the brain. Neural regeneration research. 2014 Nov 1;9(21):1912.

(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281431/?report=reader)

Kozic DB, Semnic R, Petrovic I, Svetel M, Ostojic J, Kostic VS. Are irreversible morpholocical signs of portal hypertension in neurological form of Wilson’s disease associated with treatment delay? A pilot study. Acta neurologica belgica. 2012 Sep 1;112(3):261-4.

(https://link.springer.com/article/10.1007/s13760-012-0025-1)

Van Wassenaer-van Hall HN, Van den Heuvel AG, Algra A, Hoogenraad TU, Mali WP. Wilson disease: findings at MR imaging and CT of the brain with clinical correlation. Radiology. 1996 Feb;198(2):531-6.

(https://pubs.rsna.org/doi/abs/10.1148/radiology.198.2.8596862)

Braffman BH. The aging brain and neurodegenerative disorders. InNeuroimaging 2000 (pp. 951-978). Springer, New York, NY.

(https://link.springer.com/chapter/10.1007/978-1-4612-1152-5_26)

Kozić D, Svetel M, Petrović B, Dragašević N, Semnic R, Kostić VS. MR imaging of the brain in patients with hepatic form of Wilson's disease. European journal of neurology. 2003 Sep 1;10(5):587-92.

(https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1468-1331.2003.00661.x)

Refbacks

There are currently no refbacks.